How to Reduce Costs for Specialty Medications and Injectables: 2026 Strategies

How to Reduce Costs for Specialty Medications and Injectables: 2026 Strategies

Graham Everly
February 4, 2026

Specialty medicationsHigh-cost pharmaceutical products used to treat complex chronic conditions like cancer, rheumatoid arthritis, multiple sclerosis, and hepatitis C, often requiring special handling, administration, and monitoring. make up just 2% of all prescriptions but account for half of all pharmacy spending. For many patients, these drugs can be a financial burden. But there are proven ways to reduce these costs.

Formulary Management Strategies

Formulary management is a foundational approach to controlling specialty medication costs. This involves setting clear rules for when and how these drugs are prescribed. Key strategies include prior authorization requirements, step therapy protocols, and quantity limits. For example, Excellus BlueCross BlueShield implemented a structured GLP-1 medication prior authorization process that generated $13.64 in savings per member per month compared to national pharmacy benefit manager (PBM) formularies. These rules ensure that patients only receive medications when clinically appropriate, preventing unnecessary spending.

Narrow Pharmacy Networks

Limited pharmacy networks can significantly lower costs. By contracting with a smaller number of specialty pharmacies, organizations often secure better pricing and service quality. CarelonRx reports that narrow networks typically result in 10-15% lower contractual rates. A Children's Hospital Association case study showed preferred CVS specialty pharmacy networks saved 10% on $1.3 billion in gross drug spend over three years. However, it's important to balance cost savings with patient access. Some employers initially faced member resistance when switching networks, but clear communication and support services helped ease the transition.

Biosimilar Adoption

Biosimilars are FDA-approved copies of biologic drugs that cost about 50% less than the original. Quantum Health (2023) reported that FDA-approved biosimilars could save the industry $180 billion over five years. For example, switching from the reference biologic to a biosimilar for rheumatoid arthritis treatment can reduce costs from $2,000 per month to around $1,000. Despite this potential, adoption remains challenging due to prescriber unfamiliarity and patient concerns. Healthcare systems that invest in provider education and patient counseling see higher acceptance rates and better cost savings.

Doctor comparing two syringes with different glow colors.

Treatment Setting Optimization

Where you receive treatment matters. Many specialty injectables can be administered outside expensive hospital settings. Prime Therapeutics identified 220 specialty drugs where hospital-based administration wasn't clinically necessary. Shifting these to medical offices or home settings reduced costs by 48%. For instance, an infusion therapy for multiple sclerosis that costs $500 per dose in a hospital might only cost $250 in a clinic. This change requires coordination between doctors, pharmacies, and patients, but the savings are substantial and often don't affect care quality.

Financial Assistance Programs

Many patients qualify for financial help that can reduce out-of-pocket costs. Copay maximizer programs prevent manufacturer assistance from counting toward deductibles, allowing patients to pay $0 out of pocket while reducing employer costs. CarelonRx documented that these programs help employers save money by reducing their share of the costs. For instance, a patient with a $5,000 monthly drug cost might use a copay maximizer to pay only $50 while the manufacturer covers the rest. This approach ensures patients get needed medications without financial strain.

Healthcare team working together under sunrise.

Combining Strategies for Maximum Savings

No single strategy works alone. Experts agree that combining formulary management, narrow networks, biosimilar adoption, treatment setting optimization, and financial assistance programs delivers the best results. A Health Affairs Scholar panel found that payment limit policies and reimbursement changes, when used together, offer the most comprehensive approach. Employers who implement multiple strategies see savings of 5-8% annually on specialty drug costs. As the market grows, integrated approaches will become even more critical to managing costs without sacrificing patient care.

Frequently Asked Questions

What are specialty medications?

Specialty medications are high-cost pharmaceutical products used to treat complex chronic conditions like cancer, rheumatoid arthritis, multiple sclerosis, and hepatitis C. They often require special handling, administration, and monitoring. Despite making up only 2% of prescriptions, they account for 50% of pharmacy spending.

How do biosimilars help reduce costs?

Biosimilars are FDA-approved copies of biologic drugs that cost about 50% less than the original. For example, switching to a biosimilar for rheumatoid arthritis treatment can reduce costs from $2,000 per month to around $1,000. Quantum Health reports that FDA-approved biosimilars could save the industry $180 billion over five years. While adoption has been slow due to prescriber familiarity issues, education programs are improving acceptance rates.

What is formulary management?

Formulary management involves setting rules for prescribing specialty medications, including prior authorization, step therapy, and quantity limits. For example, Excellus BlueCross BlueShield's structured GLP-1 prior authorization process saved $13.64 per member per month. This approach ensures medications are used appropriately, preventing unnecessary spending while maintaining clinical quality.

Can switching to a narrow pharmacy network save money?

Yes, limiting pharmacy networks to preferred providers typically results in 10-15% lower costs. CarelonRx found that narrow networks improve contractual rates and service quality. A Children's Hospital Association case study showed preferred CVS specialty pharmacy networks saved 10% on $1.3 billion in drug spend over three years. Initial member resistance can occur, but clear communication and support services help smooth the transition.

How does treatment setting optimization work?

Many specialty injectables can be administered outside hospitals at lower costs. Prime Therapeutics identified 220 drugs where hospital administration wasn't necessary. Shifting these to clinics or home settings reduced costs by 48%. For example, an infusion therapy costing $500 per dose in a hospital might cost $250 in a clinic. This requires coordination but doesn't compromise care quality.

What financial assistance programs are available?

Copay maximizer programs prevent manufacturer assistance from counting toward deductibles, allowing patients to pay $0 out of pocket while reducing employer costs. CarelonRx documented that these programs help employers save money by lowering their share of costs. For instance, a patient with a $5,000 monthly drug cost might pay only $50 while the manufacturer covers the rest, ensuring access without financial strain.

How do pharmacy benefit managers (PBMs) affect costs?

PBMs negotiate drug prices and manage formularies for health plans. Their role can impact costs significantly. For example, Excellus BlueCross BlueShield's formulary management through PBMs saved $13.64 per member per month on GLP-1 drugs. However, PBMs also have rebates and fees that may affect net costs. Transparency in PBM practices is crucial for effective cost management.

What role does the Inflation Reduction Act play?

The Inflation Reduction Act allows Medicare to negotiate drug prices, which could influence private market strategies. While it currently applies to Medicare, experts predict it may expand to private insurers. This could lower costs for specialty medications, though implementation details are still evolving. For now, employers and patients should monitor policy changes closely.

How can employers manage specialty drug costs?

Employers can implement multiple strategies: formulary management, narrow pharmacy networks, biosimilar adoption, and treatment setting optimization. A 2023 Business Group on Health survey found 78% of large employers use at least three cost management strategies. Combining these approaches typically saves 5-8% annually on specialty drug costs while maintaining quality care.

15 Comments

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    divya shetty

    February 5, 2026 AT 03:50

    Prior authorization must be strictly enforced without exceptions.
    Any deviation from this protocol is unacceptable and endangers public health.
    This approach is non-negotiable for fiscal responsibility.
    Pharmaceutical companies are exploiting patients with high costs.

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    Phoebe Norman

    February 6, 2026 AT 23:19

    Formulary management is critical for specialty meds.
    Prior auth step therapy quantity limits all necessary.
    Narrow networks reduce costs 10-15%.
    Biosimilars save 50% but adoption slow due to prescriber concerns.
    Need education

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    Jennifer Aronson

    February 7, 2026 AT 02:44

    It's interesting how different countries handle specialty medications.
    In the US, formulary management and biosimilars are key, but in other regions, the approach varies.
    A global perspective could offer more insights into sustainable cost reduction.

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    Kate Gile

    February 8, 2026 AT 03:32

    While strict protocols are important, it's also crucial to balance access with cost control.
    Maybe we can explore more flexible prior authorization criteria that still ensure appropriate use.
    Collaboration between payers and providers can lead to better outcomes for everyone.

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    Johanna Pan

    February 9, 2026 AT 20:38

    Biosimilars are a game changer! They cut costs in half and are FDA approved.
    We need more education for prescribers to increase adoption.
    It's definately possible to save billions!

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    Sam Salameh

    February 11, 2026 AT 19:27

    US healthcare is the best in the world!
    Our strategies for specialty meds are top-notch.
    Other countries should look to us for guidance.
    We're leading the way in cost savings and patient care.
    America first!

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    Nancy Maneely

    February 11, 2026 AT 23:31

    Oh please! Flexibility in prior auth is a disaster waiting to happen.
    Patients will abuse the system and costs will skyrocket.
    We need strict rules.
    The US is the only country that does this right.
    Others are simply not equipped!

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    Albert Lua

    February 13, 2026 AT 06:44

    Great point about biosimilars!
    In many Asian countries, biosimilar adoption is higher due to government policies.
    For example, Japan has a strong biosimilar market which helps reduce costs significantly.
    It's a great model for the US to consider.

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    Dr. Sara Harowitz

    February 15, 2026 AT 06:02

    Yes! The US is definitely the best!
    Other countries don't have the same standards.
    We must maintain our leadership in healthcare innovation.
    Without strict oversight, costs will spiral out of control!
    It's critical!

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    Pamela Power

    February 16, 2026 AT 11:14

    How naive! Flexibility in prior authorization is a recipe for disaster.
    Only the most enlightened healthcare systems can manage this properly.
    The US is the only one with the sophistication to do it right.
    Others are simply not equipped.

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    anjar maike

    February 17, 2026 AT 18:08

    Biosimilars are cool 🌟 Japan does it well

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    Bella Cullen

    February 19, 2026 AT 03:30

    US is great but maybe other countries have good ideas too.
    Not sure about the strict rules.
    Maybe we should check other models.

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    Katharine Meiler

    February 20, 2026 AT 23:36

    Formulary management and narrow networks are essential for cost control.
    Biosimilar adoption rates must increase.
    Collaboration between stakeholders is key.
    Data shows these strategies yield significant savings.

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    Lana Younis

    February 21, 2026 AT 20:59

    It's fascinating how different countries handle specialty meds.
    In Germany, they have strong biosimilar uptake.
    The US could learn from their approach.
    Maybe more collaboration between payers and providers would help.
    It's all about finding balance.

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    Rene Krikhaar

    February 23, 2026 AT 01:24

    Specialty meds are expensive but strategies like formulary management and biosimilars work.
    Need to focus on patient access while controlling costs.
    Education for prescribers is key.
    It's possible to save money without sacrificing care.

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